Aciphex |
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It was developed
by Eisai Co. and is marketed by Janssen-Cilag as rabeprazole sodium under
the brand names Aciphex and Pariet. Pharmacology Rabeprazole is a prodrug (metabolized by the cytochrome P450 (or CYP450)) - in the acid environment of the parietal cells it turns into active sulphenamide form associated with cysteine of H+, K+ATPase (proton pump). Rabeprazole inhibits (partly reversibly) H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. Rabeprazole has anti Helicobacter pylori activity (MIC 4-16 mg/ml) and shows synergistic activity with some antibiotics. Rabeprazole has been demonstrated to be effective in patients with pathological hypersecretory activity (incl. Zollinger-Ellison Syndrome). Indications and usage gastric ulcer peptic ulcer (PUD) Maintenance of Healing of Erosive or Ulcerative GERD Healing of Erosive and Ulcerative GERD Healing of Duodenal Ulcers. Treatment of Symptomatic GERD Treatment of Pathological Hypersecretory conditions (Zollinger-Ellison) Helicobactor Pylori Eradication to Reduce Risk of Duodenal Ulcer Recurrence Contraindications hypersensitivity to Rabeprazole, substituted benzimidazoles or any of components of its pharmaceutical forms. pregnancy lactation Restriction of usage acute hepatic failure pediatric use in patients under 18 years of age (there are insufficient data about safety and efficiency of Rabeprazole in this group of patients) Side effects Rabeprazole Adverse reactions/Side effects include: In clincal trials the most common side effect assessed as possibly or probably related to ACIPHEX was Headache in 2.4% of patients vs 1.6% taking placebo. diarrhea vomiting nausea abdominal pains constipation meteorism dry mouth increased or decreased appetite asthenia headache sleeplessness vertigo thrombocytopenia granulocytopenia leukocytopenia skin eruption erythema myalgia arthralgia muscle or bone pain Drug interactions Rabeprazole decreases the concentration of ketoconazole in the plasma (in 33%), increases the concentration of digoxin (in 22%), and does not interact with liquid antiacids. Rabeprazole is compatible with any medicine metabolized by the CYP450 (theophylline, warfarin, diazepam, phenytoin). Overdosage There is no available data on symptoms of rabeprazole overdose. How supplied Rabeprazole as Aciphex,Rabeloc, Pariet is supplied in: Tablet, Enteric-Coated; 10mg Tablet, Enteric-Coated; 20mg |